Sara Poletti

Jun 7, 2024 | nature.com | Sara Poletti |Francesco Benedetti

AbstractMajor depressive disorder (MDD) and bipolar disorder (BD) are highly disabling illnesses defined by different psychopathological, neuroimaging, and cognitive profiles. In the last decades, immune dysregulation has received increasing attention as a central factor in the pathophysiology of these disorders.

Jan 10, 2024 | nature.com | Francesco Benedetti |Kathryn Cullen |Ian H. Gotlib |J Hamilton |Thomas Lancaster |Sara Poletti | +5 more

AbstractMachine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by small sample sizes, lack of representativeness, data leakage, and/or overfitting.

Jul 14, 2023 | biologicalpsychiatryjournal.com | Sara Poletti

White matter (WM) alterations are a consistent finding in major depressive disorder (MDD), especially in interhemispheric tracts connecting frontal lobes ( 1 van Velzen L.S. Kelly S. Isaev D. Aleman A. Aftanas L.I. Bauer J. et al. White matter disturbances in major depressive disorder: A coordinated analysis across 20 international cohorts in the ENIGMA MDD working group. Mol Psychiatry.