Sarafan ChEm-H

Oct 9, 2024 | academic.oup.com | Sarafan ChEm-H |Chan Zuckerberg Biohub

Distinct cell type changes underlie many genitourinary disease etiologies (1). While current clinical urine assays can help guide diagnostic differentials, they lack high-resolution insights and diagnosis oftentimes requires an invasive biopsy. For example, renal tubular epithelia and prostate epithelia are regarded as the respective cell of origin for renal carcinomas and prostate adenocarcinomas.

Jan 19, 2024 | diabetesjournals.org | Sarafan ChEm-H

Regular physical activity can help reduce the incidence of obesity and obesity-associated metabolic diseases (1–3). In contrast, physical inactivity has become increasingly common in the U.S. population (4), representing a significant modifiable risk factor for cardiovascular diseases, obesity, diabetes, cancer, and overall mortality (5,6). Understanding the molecules and pathways involved in physical activity’s cardiometabolic benefits has garnered significant interest (7).

Feb 2, 2023 | cell.com | Howard Chang |Lei Qi |Chan Zuckerberg Biohub |Sarafan ChEm-H

Sabin L. Delás M. Hannon G. Dogma derailed: the many influences of RNA on the genome. Mol Cell. 2013; 49: 783-794https://doi.org/10.1016/j.molcel.2013.02.010Millman A. Bernheim A. Stokar-Avihail A. Fedorenko T. Voichek M. Leavitt A. Oppenheimer-Shaanan Y. Sorek R. Bacterial Retrons Function In Anti-Phage Defense. Cell. 2020; 183: 1551-1561.e12https://doi.org/10.1016/j.cell.2020.09.065Hsu P. Lander E. Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. Cell.