Sarah Sure

Nov 11, 2024 | biorxiv.org | Alexandra Steina |Sarah Sure |Markus Butz |Jan Vesper

AbstractBackgroundEssential tremor is hypothesized to emerge from synchronized oscillatory activity within the cerebello-thalamo-cortical circuit. However, this hypothesis has not yet been tested using local field potentials directly recorded from the thalamus alongside signals from both the cortex and cerebellum, leaving a gap in the understanding of essential tremor. ObjectivesTo clarify the importance of cerebello-thalamo-cortical oscillatory coupling for essential tremor.

Feb 21, 2024 | movementdisorders.onlinelibrary.wiley.com | Alexandra Steina |Markus Butz |Jan Vesper |Sarah Sure

Essential tremor (ET) is the most common movement disorder with a global prevalence of 0.32% across all ages.1 ET patients suffer primarily from isolated upper limb intention tremor and postural tremor.2-4 The underlying pathophysiology is only partially understood, but abnormalities in the cerebello-thalamo-cortical circuit seem to play a key role in the generation of tremor.4-7 Deep brain stimulation (DBS) of the ventral intermediate nucleus of the thalamus (VIM) is a standard therapy to...