Sasirekha Ramani

2 weeks ago | biorxiv.org | Gurpreet Kaur |Sue Crawford |Sasirekha Ramani |B. Vijayalakshmi Ayyar

AbstractHuman noroviruses (HuNoVs), the leading cause of viral gastroenteritis, can now be cultivated in human intestinal enteroids (HIEs). However, indefinite passaging of HuNoVs in HIEs remained a challenge, necessitating the use of patient stool samples as viral inocula. Using RNA-seq, we identified host restriction factors that might limit viral passaging. CXCL10, CXCL11, and CCL5 were among the most upregulated chemokines, suggesting their potential as host restriction factors.

Feb 4, 2025 | contagionlive.com | Sophia Abene |Sasirekha Ramani

A recent study published in the Journal of Virology suggests that 2′-fucosyllactose (2′FL), a sugar found in human breast milk, may provide a new treatment for human norovirus (HuNoV), a leading cause of gastroenteritis. The study focused on the GII.4 Sydney [P16] strain of HuNoV and found that 2′FL could block the virus from entering and replicating in lab-grown human intestinal models.

Jan 23, 2025 | contagionlive.com | Sophia Abene |Sasirekha Ramani

A recent study in the Journal of Virology suggests that 2′-fucosyllactose (2′FL), a sugar found in human breast milk, may offer a treatment for human norovirus (HuNoV), a leading cause of gastroenteritis. The study focused on the GII4 Sydney (P16) strain of HuNoV, found that 2′FL can block the virus from entering and replicating in lab-grown human intestinal models. Human norovirus, responsible for widespread vomiting and diarrhea, currently lacks targeted antiviral treatments.