Sue Crawford

2 weeks ago | biorxiv.org | Gurpreet Kaur |Sue Crawford |Sasirekha Ramani |B. Vijayalakshmi Ayyar

AbstractHuman noroviruses (HuNoVs), the leading cause of viral gastroenteritis, can now be cultivated in human intestinal enteroids (HIEs). However, indefinite passaging of HuNoVs in HIEs remained a challenge, necessitating the use of patient stool samples as viral inocula. Using RNA-seq, we identified host restriction factors that might limit viral passaging. CXCL10, CXCL11, and CCL5 were among the most upregulated chemokines, suggesting their potential as host restriction factors.