Scott C. Tadler

Apr 10, 2023 | biologicalpsychiatryjournal.com | Keith Jones |Robert Welsh |Scott C. Tadler

Gamma-aminobutyric acid (GABA) has been shown to be altered in patients with major depressive disorder. In the medial prefrontal cortex, an important area for self-referential memory and rumination, GABA tends to be lower in depressed individuals. This situation may be rescued by effective antidepressants, many of which involve GABAergic action. There is recent evidence that propofol, a common anesthetic and GABA-A positive allosteric modulator, has antidepressant effects at high doses.