Sean P Spencer

Feb 25, 2024 | nature.com | Sean P Spencer

Resistant starch is a prebiotic fibre that is fermented by the gut microbiota and leads to benefits for host physiology. A clinical trial in Nature Metabolism demonstrates weight loss when resistant starch was given to individuals with excess weight.

May 10, 2023 | nature.com | Dari Shalon |Rebecca Neal Culver |Jessica A. Grembi |Handuo Shi |Florian A. Rosenberger |Sean P Spencer | +5 more

AbstractThe spatiotemporal structure of the human microbiome1,2, proteome3 and metabolome4,5 reflects and determines regional intestinal physiology and may have implications for disease6. Yet, little is known about the distribution of microorganisms, their environment and their biochemical activity in the gut because of reliance on stool samples and limited access to only some regions of the gut using endoscopy in fasting or sedated individuals7.