Sebastian Siehl

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Articles

The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research - Molecular Psychiatry

Apr 23, 2024 | nature.com | Nilakshi Vaidya |Andre F. Marquand |André Marquand |Sebastian Siehl

AbstractEnvironmental experiences play a critical role in shaping the structure and function of the brain. Its plasticity in response to different external stimuli has been the focus of research efforts for decades. In this review, we explore the effects of adversity on brain’s structure and function and its implications for brain development, adaptation, and the emergence of mental health disorders.
A stable and replicable neural signature of lifespan adversity in the adult brain - Nature Neuroscience

Aug 21, 2023 | nature.com | Seyed Mostafa Kia |Sebastian Siehl |Sylvane Desrivières |Herta Flor |Penny Gowland |Andreas Heinz | +13 more

AbstractEnvironmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiological heterogeneity with behavior have yet to be elucidated.

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