Nilakshi Vaidya

Jul 1, 2024 | nature.com | Tobias Banaschewski |Sylvane Desrivières |Herta Flor |Penny Gowland |Andreas Heinz |Rüdiger Brühl | +9 more

AbstractPerseverative negative thoughts, known as rumination, might arise from emotional challenges and preclude mental health when transitioning into adulthood. Due to its multifaceted nature, rumination can take several ruminative response styles, that diverge in manifestations, severity, and mental health outcomes. Still, prospective ruminative phenotypes remain elusive insofar.

Apr 23, 2024 | nature.com | Nilakshi Vaidya |Andre F. Marquand |André Marquand |Sebastian Siehl

AbstractEnvironmental experiences play a critical role in shaping the structure and function of the brain. Its plasticity in response to different external stimuli has been the focus of research efforts for decades. In this review, we explore the effects of adversity on brain’s structure and function and its implications for brain development, adaptation, and the emergence of mental health disorders.

Oct 19, 2023 | nature.com | Tobias Banaschewski |Gareth Barker |Sylvane Desrivières |Herta Flor |Penny Gowland |Andreas Heinz | +17 more

AbstractThe cerebral ventricles are recognized as windows into brain development and disease, yet their genetic architectures, underlying neural mechanisms and utility in maintaining brain health remain elusive. Here we aggregated genetic and neuroimaging data from 61,974 participants (age range, 9 to 98 years) in five cohorts to elucidate the genetic basis of ventricular morphology and examined their overlap with neuropsychiatric traits.