Sébastien Maillé

Jun 26, 2024 | biorxiv.org | Michael Lynn |Sean Geddes |Mohamad A. Chahrour |Sébastien Maillé

AbstractSerotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) receive a constellation of long-range inputs, yet guiding principles of local circuit organization and underlying computations in this nucleus are largely unknown. Using inputs from the lateral habenula (LHb) to interrogate the processing features of the DRN, we uncovered 5-HT1A receptor-mediated recurrent connections between 5-HT neurons, refuting classical theories of autoinhibition.