Sebin Hong

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Human hypothalamic neural stem cells transplantation ameliorates age-associated dysfunction through SNS/eNAMPT axis activation in aged mice

1 month ago | biorxiv.org | Yanuar Alan Sulistio |Kelvin Pieknell |Sebin Hong |Yuna Lee

AbstractThe hypothalamus is the brain region that regulates systemic body metabolism and multiple brain functions. The adult hypothalamus harbors neural stem/precursor cell (NSC)-like cells. Along with age-related body changes, the hypothalamic NSC (htNSC) population declines, indicating the potential of htNSC replacement as an anti-aging strategy. Here, we developed protocol to generate htNSCs from human pluripotent stem cells (hPSCs).

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