Seong Won Kim

Jan 2, 2025 | jci.org | Bryan Wang |Seong Won Kim |Lori Luo |Xiaokan Zhang |Rajesh Kumar Soni |Roberta Lock | +11 more

AbstractLoss of Bcl2-associated athanogene 3 (BAG3) is associated with dilated cardiomyopathy (DCM). BAG3 regulates sarcomere protein turnover in cardiomyocytes; however, the function of BAG3 in other cardiac cell types is understudied. In this study, we used an isogenic pair of BAG3-knockout and wild-type human induced pluripotent stem cells (hiPSCs) to interrogate the role of BAG3 in hiPSC-derived cardiac fibroblasts (CFs).