Xiaokan Zhang

Jan 2, 2025 | jci.org | Bryan Wang |Seong Won Kim |Lori Luo |Xiaokan Zhang |Rajesh Kumar Soni |Roberta Lock | +11 more

AbstractLoss of Bcl2-associated athanogene 3 (BAG3) is associated with dilated cardiomyopathy (DCM). BAG3 regulates sarcomere protein turnover in cardiomyocytes; however, the function of BAG3 in other cardiac cell types is understudied. In this study, we used an isogenic pair of BAG3-knockout and wild-type human induced pluripotent stem cells (hiPSCs) to interrogate the role of BAG3 in hiPSC-derived cardiac fibroblasts (CFs).

Aug 20, 2024 | newswise.com | Xiaokan Zhang

Tiny Killers: How Autoantibodies Attack the Heart in Lupus PatientsDeck: Columbia team engineers a model of the human heart tissue that demonstrates how autoantibodies directly affect heart disease in lupus patientsNew York, NY—August 20, 2024—Cardiovascular disease is the leading cause of death in patients suffering from lupus, an autoimmune disease in which our immune system attacks our own tissues and organs, the heart, blood, lung, joints, brain, and skin.

Mar 14, 2023 | cell.com | Bryan Wang |Trevor Nash |Xiaokan Zhang |Jenny Rao

Muchtar E. Blauwet L.A. Gertz M.A. Restrictive cardiomyopathy: genetics, pathogenesis, clinical manifestations, diagnosis, and therapy. Circ. Res. 2017; 121: 819-837https://doi.org/10.1161/CIRCRESAHA.117.310982Felker G.M. Thompson R.E. Hare J.M. Hruban R.H. Clemetson D.E. Howard D.L. Baughman K.L. Kasper E.K. Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. N. Engl. J. Med.