Sergey V. Venev

Feb 22, 2024 | nature.com | Jake Lee |Doga C. Gulhan |Sergey V. Venev |Eric Wooten |Kamila Naxerova |Job Dekker | +1 more

AbstractWhole chromosome and arm-level copy number alterations occur at high frequencies in tumors, but their selective advantages, if any, are poorly understood. Here, utilizing unbiased whole chromosome genetic screens combined with in vitro evolution to generate arm- and subarm-level events, we iteratively selected the fittest karyotypes from aneuploidized human renal and mammary epithelial cells.