Shan Yan

Jan 19, 2025 | advanced.onlinelibrary.wiley.com | Qi Yu |Qin Zhang |Shan Yan

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202419386-sup-0001-SuppMat.docx7.2 MB Supporting Information References 1a) , , , , , , Oncogene 2014, 33, 1743; b) , , , , , Signal Transduction Targeted Ther. 2023, 8, 70; c) , , , , , , , , , , , , , , , , , , , , , , , Nat. Genet. 2019, 51, 308. 2a) , Nat. Rev. Cancer 2003, 3, 721; b) , , , , , , , , , , , , Adv. Funct. Mater. 2020, 30, 2003338; c) , , J.

Mar 16, 2023 | cell.com | Jia Li |Shan Yan

Ribosomal DNA (rDNA) is transcribed into RNA in the nucleolus and is often challenged by different stress conditions. However, the underlying mechanisms of nucleolar DNA damage response (DDR) pathways remain elusive. Here, we provide distinct perspectives on how nucleolar DDR checkpoint pathways are activated by different stresses or by liquid–liquid phase separation (LLPS).