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2 months ago | 00058-3?rss=yes&sz=64)
cell.com | Cynthia Palmer |Britton Boras |Scott Garza |Jing Yuan |Tae Sung |Elizabeth McMillan | +45 more
KeywordsatirmociclibPF-07220060CDK4cyclin D1breast cancercell cyclecell cycle inhibitorneutropeniacyclin-dependent kinaseCDK6IntroductionAberrant cell proliferation is a fundamental hallmark of human cancer.1 In tumor cells, it is frequently orchestrated by cyclin D-dependent kinases, CDK4 and CDK6; each kinase forms active complexes with one of the three D-type cyclins (D1, D2, or D3).
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Jan 19, 2025 | 
advanced.onlinelibrary.wiley.com | Qi Yu |Qin Zhang |Shan Yan
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202419386-sup-0001-SuppMat.docx7.2 MB Supporting Information References 1a) , , , , , , Oncogene 2014, 33, 1743; b) , , , , , Signal Transduction Targeted Ther. 2023, 8, 70; c) , , , , , , , , , , , , , , , , , , , , , , , Nat. Genet. 2019, 51, 308. 2a) , Nat. Rev. Cancer 2003, 3, 721; b) , , , , , , , , , , , , Adv. Funct. Mater. 2020, 30, 2003338; c) , , J.
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Dec 10, 2024 | 
mdpi.com | Lu Zhao |Jun Teng |Chao Ning |Qin Zhang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Oct 10, 2024 | 
alzres.biomedcentral.com | Yaru Yang |Hongyan Qiu |Yuru Fan |Qin Zhang |Huiling Qin |Juan Wu | +9 more
Two randomized, double-blind, single-ascending-dose, phase 1 studies were conducted concurrently in China (Study CHN; NCT04973189) and Australia (Study AUS; NCT04745104). Study CHN consisted of two parts, with Part 1 involving healthy young subjects aged 18–45 years and Part 2 involving healthy elderly subjects aged 55–80 years.
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Oct 8, 2024 | 
mdpi.com | Qin Zhang |Yanan Li |Sha Geng |Qian Liu
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Oct 8, 2024 | 
nature.com | Qin Zhang
replying to A. Tasegian et al. Nature Immunology https://doi.org/10.1038/s41590-024-01972-0 (2024)We read the comments by Tasegian et al. related to our article published in Nature Immunology, entitled ‘Commensal bacteria direct selective cargo sorting to promote symbiosis’1, with keen interest. In Zhang et al.1, we reported a Nod2-LRRK2-dependent lysozyme-sorting phenomenon in Paneth cells.
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Oct 7, 2024 | 
journals.plos.org | Wei Liu |Zhenguo Qiao |Yan Xu |Qin Zhang
Citation: Liu W, Qiao Z, Xu Y, Zhang Q, Xie M, Ma C (2024) Adjusting dialysis dose (Kt) scaled to Body Surface Area (BSA) could be a more logical approach. PLoS ONE 19(10): e0311175. https://doi.org/10.1371/journal.pone.0311175Editor: Diego Moriconi, University of Pisa, ITALYReceived: June 14, 2024; Accepted: September 14, 2024; Published: October 7, 2024Copyright: © 2024 Liu et al.
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Oct 6, 2024 | 
onlinelibrary.wiley.com | Yijing Zhang |Yue Liu |Zichao Li |Qin Zhang
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202412165-sup-0001-SuppMat.docx19.8 MB Supporting Information References 1a) , , , , , , , , Physiol. Rev. 2021, 101, 797; b) , , Nat. Rev. Cancer. 2022, 22, 85; c) , , , , , , , , , , , , , , Nat. Commun. 2021, 12, 6920. 2a) , Nat. Rev. Cancer. 2002, 2, 584; b) , N. Engl. J. Med. 2004, 350, 1655. 3a) , , , , , , , , , , Nat. Rev. Dis. Primers. 2020, 6, 83; b) , , , , Nat.
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Jun 7, 2024 | 
amazon.science | Qin Zhang |Changyou Chen
In recent years, the fields of natural-language processing and computational linguistics, which were revolutionized a decade ago by deep learning, were revolutionized again by large language models (LLMs). Unsurprisingly, work involving LLMs, either as a subject of inquiry themselves or as tools for other natural-language-processing applications, predominates at this year’s meeting of the North American Chapter of the Association for Computational Linguistics (NAACL).
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Jun 5, 2024 | 
onlinelibrary.wiley.com | Qiang Huang |Qin Zhang |Bei Cao
1 INTRODUCTION Neurodegenerative diseases (NDDs) are heterogeneous neurological disorders that can lead to progressive neuronal damage in the central nervous system (CNS) or the peripheral nervous system (PNS), adversely affecting the productive lives of millions of people worldwide. Common neurodegenerative diseases include ALS, PD, AD, and other similar conditions.
