Shana J. Sturla

Sep 19, 2024 | nature.com | Ivo A. Hendriks |Norman E. Davey |Alessandra Zarantonello |Daniel R. Semlow |Shana J. Sturla |Michael Nielsen | +2 more

AbstractTranslesion DNA synthesis (TLS) is a cellular process that enables the bypass of DNA lesions encountered during DNA replication and is emerging as a primary target of chemotherapy. Among vertebrate DNA polymerases, polymerase κ (Polκ) has the distinctive ability to bypass minor groove DNA adducts in vitro. However, Polκ is also required for cells to overcome major groove DNA adducts but the basis of this requirement is unclear.