Shaochun Zhu

Aug 30, 2024 | pubs.acs.org | Xin Zhou |Shaochun Zhu |Junhong Li |André Mateus

IntroductionClick to copy section linkSection link copied!Skeletal muscle adaptation to exercise involves a multitude of phenotypic changes that contribute to improved metabolic and contractile functions. (1) These adaptations include enhanced mitochondrial quality, increased glucose uptake, and improved insulin sensitivity. (2) An essential player in these adaptive responses is the activation of AMPK (5′-AMP-activated protein kinase).

Aug 30, 2024 | dx.doi.org | Xin Zhou |Shaochun Zhu |Junhong Li |André Mateus

IntroductionClick to copy section linkSection link copied!Skeletal muscle adaptation to exercise involves a multitude of phenotypic changes that contribute to improved metabolic and contractile functions. (1) These adaptations include enhanced mitochondrial quality, increased glucose uptake, and improved insulin sensitivity. (2) An essential player in these adaptive responses is the activation of AMPK (5′-AMP-activated protein kinase).

Feb 7, 2024 | biorxiv.org | Xin Zhou |Shaochun Zhu |Junhong Li |André Mateus

AbstractSkeletal muscle adaptation to exercise involves various phenotypic changes that enhance metabolic and contractile functions. One key regulator of these adaptive responses is the activation of AMPK, influenced by exercise intensity. However, the mechanistic understanding of AMPK activation during exercise remains incomplete. In this study, we utilized an in vitro model to investigate the effects of mechanical loading on AMPK activation and its interplay with the mTOR signaling pathway.