André Mateus

Sep 4, 2024 | nature.com | Carlos Garcia-Prieto |Anna Nordin |Stephanie Stransky |Damiana Álvarez-Errico |Ludvig Lizana |Jonathan Gilthorpe | +7 more

AbstractLysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development. Here we show that LSD1 is dispensable for mouse embryonic stem cell (ESC) self-renewal but is required for mouse ESC growth and differentiation.

Sep 4, 2024 | iubmb.onlinelibrary.wiley.com | Lucia Jimenez |André Mateus |Elisabeth Baland

1 INTRODUCTION The three-dimensional (3D) structure of proteins defines their function. This 3D structure is determined by the physicochemical characteristics of the sequence of amino acids and interactions between their atoms. The structure of a protein can be experimentally resolved by using methods such as X-ray crystallography, nuclear magnetic resonance (NMR), or cryogenic electron microscopy (cryoEM).

Aug 30, 2024 | pubs.acs.org | Xin Zhou |Shaochun Zhu |Junhong Li |André Mateus

IntroductionClick to copy section linkSection link copied!Skeletal muscle adaptation to exercise involves a multitude of phenotypic changes that contribute to improved metabolic and contractile functions. (1) These adaptations include enhanced mitochondrial quality, increased glucose uptake, and improved insulin sensitivity. (2) An essential player in these adaptive responses is the activation of AMPK (5′-AMP-activated protein kinase).

Aug 30, 2024 | dx.doi.org | Xin Zhou |Shaochun Zhu |Junhong Li |André Mateus

IntroductionClick to copy section linkSection link copied!Skeletal muscle adaptation to exercise involves a multitude of phenotypic changes that contribute to improved metabolic and contractile functions. (1) These adaptations include enhanced mitochondrial quality, increased glucose uptake, and improved insulin sensitivity. (2) An essential player in these adaptive responses is the activation of AMPK (5′-AMP-activated protein kinase).

Jul 3, 2024 | nature.com | Gabriel Torrens |Rosa del Campo |André Mateus |Ana Rico |Felipe Cava |Ines Rodrigues-Lopes | +2 more

AbstractThe function of many bacterial processes depends on the formation of functional membrane microdomains (FMMs), which resemble the lipid rafts of eukaryotic cells. However, the mechanism and the biological function of these membrane microdomains remain unclear. Here, we show that FMMs in the pathogen methicillin-resistant Staphylococcus aureus (MRSA) are dedicated to confining and stabilizing proteins unfolded due to cellular stress.