Sheeja Prabhakaran

Sep 2, 2024 | ccforum.biomedcentral.com | Sheeja Prabhakaran |Sichuan province |Engineering Programme

The innate immune response plays a key role in the pathophysiology of sepsis. Upon activation, pattern recognition receptors (PRRs) initiate signaling cascades, leading to the nuclear translocation of NF-κB, interferon regulatory factor (IRF), and other transcription factors. These transcription factors initiate the production of pro-inflammatory cytokines, chemokines, type I interferons (IFNs), etc. [98].