Shenzhen Shenzhen

Sep 4, 2024 | molecularneurodegeneration.biomedcentral.com | Shenzhen Shenzhen |Neurodegenerative Diseases

Experimental designThis translational study used preclinical (n = 224) and human (n = 59) TSPO-PET imaging data, which were consistently analyzed with ICCs for assessment of regional synchronicity of the tracer signal (Fig. 1A and B). Mice with microglia depletion via colony-stimulating factor 1 receptor (CSF1R) inhibition using PLX5622 were analyzed in contrast to age-matched placebo controls as a proof-of-concept experiment.