Shibo Jiang

Mar 4, 2024 | nature.com | Lu Lu |Yong-Tang Zheng |Shibo Jiang

AbstractApart from mediating viral entry, the function of the free HIV-1 envelope protein (gp120) has yet to be elucidated. Our group previously showed that EP2 derived from one β-strand in gp120 can form amyloid fibrils that increase HIV-1 infectivity. Importantly, gp120 contains ~30 β-strands. We examined whether gp120 might serve as a precursor protein for the proteolytic release of amyloidogenic fragments that form amyloid fibrils, thereby promoting viral infection.

Jan 8, 2024 | nature.com | Yun Zhu |Shibo Jiang

Dear Editor,BA.2.86, a novel SARS-CoV-2 Omicron subvariant, has emerged along with widespread concerns since the number of mutations in its S protein exceeds that of other Omicron subvariants (Fig. 1a). On August 18, 2023, the World Health Organization formally classified BA.2.86 as a variant under monitoring (VUM)1. Notably, numerous studies have reported that BA.2.86 has evaded humoral immunity induced by both inactivated and mRNA SARS-CoV-2 vaccines, as well as COVID-19 convalescent plasma2,3.

Nov 29, 2023 | nature.com | Lu Lu |Shibo Jiang

In recent studies published in Nature and Lancet Infectious Diseases,1,2 SARS-CoV-2 Omicron subvariant BA.2.86 exhibited a substantial antigenic drift, enhanced receptor affinity, and less immune evasion to sera of individuals upon XBB breakthrough infection or reinfection.

Jun 16, 2023 | nature.com | Shibo Jiang

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Mar 15, 2023 | nature.com | Shibo Jiang

In a recent study published in Nature, Yan and colleagues demonstrated that NeoCoV, a potential MERS-CoV ancestor in bats, can use bat ACE2 as its entry receptor and that NeoCoV S pseudotyped virus, which contains a T510F mutation in the receptor-binding domain (RBD), enters cells expressing human ACE2 (hACE2).1 The findings reveal a potential zoonotic threat that MERS-CoV could, during its evolution, be gaining the ability to use hACE2 as an entry receptor and, thus, could also coinfect...