Yong-Tang Zheng

Apr 12, 2024 | liebertpub.com | Yong-Tang Zheng

Get full access to this articleView all available purchase options and get full access to this article. References1. Chun TW, Davey RT Jr., Engel D, et al. Re-emergence of HIV after stopping therapy. Nature 1999;401(6756):874–875;2. Press N, Tyndall MW, Wood E, et al. Virologic and immunologic response, clinical progression, and highly active antiretroviral therapy adherence. J Acquir Immune Defic Syndr 2002;31(Suppl 3):S112–7;3. Eisele E, Siliciano RF.

Mar 4, 2024 | nature.com | Lu Lu |Yong-Tang Zheng |Shibo Jiang

AbstractApart from mediating viral entry, the function of the free HIV-1 envelope protein (gp120) has yet to be elucidated. Our group previously showed that EP2 derived from one β-strand in gp120 can form amyloid fibrils that increase HIV-1 infectivity. Importantly, gp120 contains ~30 β-strands. We examined whether gp120 might serve as a precursor protein for the proteolytic release of amyloidogenic fragments that form amyloid fibrils, thereby promoting viral infection.

Jun 8, 2023 | nature.com | Yong-Tang Zheng

AbstractTripartite motif-containing protein 5α (TRIM5α) is generally known to block the postentry events of HIV-1. Here, we report an uncharacterized role for TRIM5α in the maintenance of viral latency. Knockdown of TRIM5α potentiates the transcription of HIV-1 in multiple latency models, which is reversed by shRNA-resistant TRIM5α. TRIM5α suppresses TNFα-activated HIV-1 LTR-driven as well as NF-κB- and Sp1-driven gene expression, with the RING and B-box 2 domains being the essential determinants.

Apr 29, 2023 | nature.com | Feng-Liang Liu |Zi-Da Zhen |Yong-Tang Zheng |Jing An

AbstractZika virus (ZIKV) is a potential threat to male reproductive health but the mechanisms underlying its influence on testes during ZIKV infection remain obscure. To address this question, we perform single-cell RNA sequencing using testes from ZIKV-infected mice.