Shiho Chiba

Sep 25, 2023 | nature.com | Yixuan Hou |Shiho Chiba |Sarah R. Leist |Rita M. Meganck |Alexandra Schafer |Rhianna E. Lee | +7 more

AbstractThe pathogenic and cross-species transmission potential of SARS-CoV-2-related coronaviruses (CoVs) remain poorly characterized. Here we recovered a wild-type pangolin (Pg) CoV GD strain including derivatives encoding reporter genes using reverse genetics. In primary human cells, PgCoV replicated efficiently but with reduced fitness and showed less efficient transmission via airborne route compared with SARS-CoV-2 in hamsters.