Shimin Le

Jan 13, 2025 | link.aps.org | Yuhang Zhang |Hao Sun |Shimin Le |Hu Chen

The cold shock domain (CSD) protein acts as a nucleic acid-binding protein and exhibits a strong affinity for the Y-box core motif ATTGG segment on gene promoter regions, playing a significant role in gene regulation. Given the moderate folding and unfolding rates of the cold shock protein from Bacillus caldolyticus (BcCsp) observed in previous magnetic tweezers studies, it is a suitable choice for investigating the interaction between CSD protein and single-stranded DNA containing ATTGG.