Shimul A. Shah

Oct 26, 2023 | sciencedirect.com | Prachi Agarwal |Shimul A. Shah

Bcl-2 family proteins are well known to have a key role in the regulation of apoptosis. The family comprises almost 20 members, divided into a prosurvival subset (Bcl-2, Bcl-xL, Mcl-1, and others), a proapoptotic ‘BH3-only’ subset (Bid, Bim, Bad, Puma, and others), and a ‘Bax/Bak’ subset that, upon activation, promotes apoptosis via formation of pores that permeabilize mitochondrial outer membranes [1,2]. Prosurvival Bcl-2 family proteins antagonize Bax/Bak activation and downstream