Shingo Ishihara

Dec 21, 2024 | arthritis-research.biomedcentral.com | Terese Geraghty |Shingo Ishihara |Alia M. Obeidat |Natalie S Adamczyk |Jun Li |Lai Wang | +5 more

Macrophage Fas-Induced Apoptosis (MaFIA) mice were purchased from Jackson laboratories (strain name: C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/J; RRID: IMSR_JAX:005070) and bred in house (homozygous x homozygous). When male mice became 12 weeks old, destabilization of the medial meniscus (DMM) surgery was performed on right knee joints, as previously described [22].

Aug 19, 2024 | biorxiv.org | Terese Geraghty |Shingo Ishihara |Alia M. Obeidat |Natalie S Adamczyk

AbstractBackground: Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally due to inadequate treatment options. Neuroimmune interactions reportedly contribute to OA pain pathogenesis. Notably, in rodents, macrophages in the DRG are associated with onset of persistent OA pain.

Apr 16, 2023 | arthritis-research.biomedcentral.com | Lai Wang |Shingo Ishihara |Jun Li |Rachel Miller |Anne-Marie Malfait

ReferencesVincent TL. Peripheral pain mechanisms in osteoarthritis. Pain. 2020;161(Suppl 1):S138–46. Article  PubMed  PubMed Central  Google Scholar  Woller SA, Eddinger KA, Corr M, Yaksh TL. An overview of pathways encoding nociception. Clin Exp Rheumatol. 2017;35 Suppl 107(5):40–6. PubMed  Google Scholar  Miller RJ, Malfait AM, Miller RE. The innate immune response as a mediator of osteoarthritis pain. Osteoarthritis Cartilage. 2020;28(5):562–71.