Terese Geraghty

Dec 21, 2024 | arthritis-research.biomedcentral.com | Terese Geraghty |Shingo Ishihara |Alia M. Obeidat |Natalie S Adamczyk |Jun Li |Lai Wang | +5 more

Macrophage Fas-Induced Apoptosis (MaFIA) mice were purchased from Jackson laboratories (strain name: C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/J; RRID: IMSR_JAX:005070) and bred in house (homozygous x homozygous). When male mice became 12 weeks old, destabilization of the medial meniscus (DMM) surgery was performed on right knee joints, as previously described [22].

Aug 19, 2024 | biorxiv.org | Terese Geraghty |Shingo Ishihara |Alia M. Obeidat |Natalie S Adamczyk

AbstractBackground: Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally due to inadequate treatment options. Neuroimmune interactions reportedly contribute to OA pain pathogenesis. Notably, in rodents, macrophages in the DRG are associated with onset of persistent OA pain.