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Oct 16, 2024 | 
digitalcommons.library.tmc.edu | Kiyohiro Houkin |Toshiya Osanai |Shinichiro Uchiyama |Kazuo Minematsu
IMPORTANCE: Cell therapy is a promising treatment approach for stroke and other diseases. However, it is unknown whether MultiStem (HLCM051), a bone marrow-derived, allogeneic, multipotent adult progenitor cell product, has the potential to treat ischemic stroke. OBJECTIVE: To assess the efficacy and safety of MultiStem when administered within 18 to 36 hours of ischemic stroke onset.
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Nov 9, 2023 | 
frontiersin.org | Ryan Ty |Hiba Naveed |Shinichiro Uchiyama |Anastasios Apostolos
1. Introduction
Early initiation of antithrombotic medications decreases the risk of recurrence of vascular events in patients with coronary artery disease (CAD), transient ischemic attack (TIA), and ischemic stroke (1–5). Numerous clinical trials during the last 50 years have provided evidence that ASA and clopidogrel reduce the risk of stroke and other vascular events when compared to placebo (6–13).
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Sep 25, 2023 | 
frontiersin.org | Shinichiro Uchiyama |Shigeru Nogawa |Koichi Oki
1 Introduction
According to the 2019 Global Burden of Disease data, stroke remains the second most common cause of mortality globally (1, 2). Acute ischemic stroke (AIS) is among the two main subcategories of stroke (3), which occurs due to focal cerebral hypoperfusion commonly caused by embolism and atherosclerotic disease (4, 5).
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Sep 19, 2023 | 
bmjopen.bmj.com | Shinichiro Uchiyama |Katsue Suzuki-Inoue |Hideo Wada |Yasushi Okada
Soluble C-type lectin-like receptor 2 in stroke (CLECSTRO) study: protocol of a multicentre, prospective cohort of a novel platelet activation marker in acute ischaemic stroke and transient ischaemic attack Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service.
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Jul 25, 2023 | 
frontiersin.org | Hua Yang |Shinichiro Uchiyama |Xu Shen |Shigeru Nogawa
Introduction
Cerebral small vessel disease (CSVD) is a group of clinical, imaging, and pathological syndromes caused by structural remodeling of small cerebral arteries and their distal branches, micro-arteries, capillaries, micro-venules, and small veins (1), frequently leading to vascular cognitive impairment (2). As the most important imaging method for the diagnosis of CSVD, brain MRI is often used to assess the severity of CSVD.
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Jul 23, 2023 | 
frontiersin.org | Shinichiro Uchiyama |Hipólito Nzwalo |Piotr Sobolewski
1. IntroductionMultiple acute ischemic stroke (MAIS) is most frequently attributed to an “embolic phenomenon,” such as atrial fibrillation (AF), the most common cause of cardioembolic stroke (1). MAIS also can be an initial presentation of malignancy that is commonly undiagnosed (2). Nearly 15% of patients with malignancy experience cerebrovascular events (3), and 1 in 10 patients admitted with acute ischemic stroke (AIS) have comorbid malignancy (4).
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Jul 8, 2023 | 
frontiersin.org | Shinichiro Uchiyama |Bruno Bonetti |Koichi Oki
1. IntroductionMechanical thrombectomy (MT) has been proven to be an effective treatment for acute ischemic stroke (AIS) with anterior circulation large-vessel occlusion and was established as the new standard of care in recent years (1–3). Nonetheless, there is still a significant proportion of patients who fail to achieve favorable outcomes, and 28.6–67.8% of patients have poor functional outcomes after MT therapy (4).
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Jun 1, 2023 | 
frontiersin.org | Shandong Engineering |Slaven Pikija |Yueqi Zhu |Shinichiro Uchiyama
Introduction
Antiplatelet therapy is recommended after non-cardiogenic ischemic stroke, aiming at limiting thrombosis on ulcer atherosclerotic plaque and subsequent distal embolism (1). Dual antiplatelet therapy (DAPT) with a P2Y12 receptor inhibitor is often recommended after neuroendovascular stenting, with a transition to aspirin monotherapy after follow-up endovascular angiography (2, 3).
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May 11, 2023 | 
frontiersin.org | Shinichiro Uchiyama |Takao Hoshino |Lucy Thomas |Koichi Oki
1. Introduction
Cervical artery dissection (CAD) is one of the major causes of stroke in young and middle-aged adults, often caused by neck distortion, chiropractic manipulation, and trauma (1–3). Patients with CAD can have a wide range of symptoms, varying from completely asymptomatic to a fatal stroke. Typically, CADs present symptoms such as headache or neck pain and a partial Horner's syndrome, followed by retinal or cerebral ischemia (4–6).
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Apr 13, 2023 | 
frontiersin.org | Nagoya City |Shinichiro Uchiyama |Shigeru Nogawa |Shunya Takizawa
1. IntroductionIntracerebral hemorrhage (ICH) accounts for approximately 10–15% of all strokes and is associated with high morbidity and mortality (1–5). It has been reported that Asian populations (especially Japanese) experience ICH more frequently than Western populations (5, 6). Hypertension is the risk factor with the greatest influence on primary ICHs, and it is present in approx. 70% of patients who experience an ICH (7).
