Shivam Vora

Jan 7, 2025 | nature.com | Shivam Vora |Deborah Nazareth |John Hooper |Daniela Cimini |JING CHEN

AbstractPolyploidy is a common outcome of chemotherapies, but there is conflicting evidence as to whether polyploidy is an adverse, benign or even favourable outcome. We show Aurora B kinase inhibitors efficiently promote polyploidy in many cell types, resulting in the cell cycle exit in RB and p53 functional cells, but hyper-polyploidy in cells with loss of RB and p53 function.