Shiyue WANG

May 6, 2024 | biorxiv.org | Yuchen He |Jia Xing |Shiyue WANG |Han Jiang

AbstractObjective: Despite surgical advance, effective targeted drugs for non-surgical treatment of abdominal aortic aneurysm (AAA) are lacking because of the unclear pathogenesis of AAA. N6-methyladenosine (m6A) methylation, acknowledged for its pivotal influence on RNA metabolism, including aspects such as stability, transport, translation, and splicing, is largely implied for its role in AAA mechanism.

Sep 29, 2023 | biorxiv.org | Yuchen He |Jia Xing |Shiyue WANG |Han Jiang

AbstractObjective: Abdominal aortic aneurysm (AAA) is a life-threatening disease in vascular surgery with significant morbidity and mortality rates upon rupture. Despite surgical interventions, effective targeted drugs for non-surgical candidates are lacking. M6A methylation, a dynamic RNA modification, has been implicated in various diseases, but its role in AAA remains poorly understood.

Jul 17, 2023 | mdpi.com | Shiyue WANG |Xin Li |Han Jiang |Jian Zhang

4. DiscussionTo the best of our knowledge, the present study is the first to report that serum Vcn and VEC may represent useful circulating biomarkers of TBAD. TBAD is a serious disease that requires vascular surgery and is characterized by a tear in the descending aorta, high mortality, and morbidity [13]. Endothelial injury is considered to be an important component of the pathogenesis of TBAD [14,15].