Yuchen He

May 6, 2024 | biorxiv.org | Yuchen He |Jia Xing |Shiyue WANG |Han Jiang

AbstractObjective: Despite surgical advance, effective targeted drugs for non-surgical treatment of abdominal aortic aneurysm (AAA) are lacking because of the unclear pathogenesis of AAA. N6-methyladenosine (m6A) methylation, acknowledged for its pivotal influence on RNA metabolism, including aspects such as stability, transport, translation, and splicing, is largely implied for its role in AAA mechanism.

May 6, 2024 | onlinelibrary.wiley.com | Yuchen He |Yishu Fan |Yumin Wang |Xenab Ahmadpoor

1 INTRODUCTION Lysosomes, first described by Dr. de Duve about 70 years ago, have been recognized as the primary degradative compartment in eukaryotic cells.1 Studies in the past have revealed their characteristics as highly acidic, dynamic, heterogeneous single membrane cellular organelles with varying sizes, locations, morphology, enzyme content, substrates, and functions.

Sep 29, 2023 | biorxiv.org | Yuchen He |Jia Xing |Shiyue WANG |Han Jiang

AbstractObjective: Abdominal aortic aneurysm (AAA) is a life-threatening disease in vascular surgery with significant morbidity and mortality rates upon rupture. Despite surgical interventions, effective targeted drugs for non-surgical candidates are lacking. M6A methylation, a dynamic RNA modification, has been implicated in various diseases, but its role in AAA remains poorly understood.