Shuvadeep Maity

Mar 7, 2024 | cell.com | Shuvadeep Maity |Science Pilani |Hyderabad Campus |Lauren Jeffery

Highlights • Induced spinal/cranial motor neurons (iSpMNs/iCrMNs) have dynamic transcriptomes/proteomes • More stress-sensitive iSpMNs are enriched in proteins from DNA/RNA metabolism • More stress-resistant iCrMNs are enriched in proteostasis and neuronal function proteins • Higher 26S proteasome activity and Ublcp1 levels contribute to stress resistance in iCrMN Summary Amyotrophic lateral sclerosis damages proteostasis, affecting spinal and upper motor neurons earlier than a subset of...