Siena M Centofanti

Oct 13, 2024 | biorxiv.org | Stephen Johnson |Michael Beard |Siena M Centofanti |Gustavo Bracho

AbstractSecreted non-structural protein 1 (sNS1) is an important orthoflavivirus pathogenic factor that can induce vascular leakage; a key symptom of severe dengue disease. Given the role of sNS1 in dengue pathogenesis, defining the molecular mechanisms of NS1 secretion may contribute towards development of NS1-targeting antiviral therapies. To this end, we performed a customised membrane-trafficking siRNA screen to identify human host factors involved in NS1 secretion.