Sihan Wu

Apr 12, 2023 | nature.com | Jens Luebeck |Patricia C. Galipeau |Xiaohong Li |Carlo C. Maley |Howard Chang |Sihan Wu | +1 more

ecDNA detection and characterizationDNA copy number alterations were detected using CNVKit (ref. 47; FHCC and TCGA samples) and ASCAT (ref. 48; Cambridge samples). AmpliconSuite-pipeline (v.0.1203.12) was used to identify candidate seed regions for the detection and characterization of ecDNA using AmpliconArchitect v.1.2 (ref. 21) and AmpliconClassifier (v.0.4.13) (Supplementary Information and Fig.