Silviu-Alin Bacanu

Nov 20, 2023 | nature.com | Andrew Dahl |Ulzee An |Morten Krebs |Vivek Appadurai |Silviu-Alin Bacanu |Thomas Werge | +3 more

AbstractBiobanks often contain several phenotypes relevant to diseases such as major depressive disorder (MDD), with partly distinct genetic architectures. Researchers face complex tradeoffs between shallow (large sample size, low specificity/sensitivity) and deep (small sample size, high specificity/sensitivity) phenotypes, and the optimal choices are often unclear. Here we propose to integrate these phenotypes to combine the benefits of each.