Simon L. Priestnall

Apr 12, 2024 | nature.com | Luke S. Cox |Claire Pearson |Simon L. Priestnall |Anna Mikolajczak |James Briscoe |Fiona Powrie | +2 more

AbstractIntestinal immune responses to microbes are controlled by the cytokine IL-10 to avoid immune pathology. Here, we use single-cell RNA sequencing of colon lamina propria leukocytes (LPLs) along with RNA-seq and ATAC-seq of purified CD4+ T cells to show that the transcription factors Blimp-1 (encoded by Prdm1) and c-Maf co-dominantly regulate Il10 while negatively regulating proinflammatory cytokines in effector T cells.