Simon Schneider

1 week ago | publications.ersnet.org | Arcangelo Carta |Stéphanie Saxer |Laura Mayer |Simon Schneider

IntroductionPatients with pulmonary vascular disease (PVD) defined by precapillary pulmonary hypertension (PH) and diagnosed as pulmonary arterial hypertension (PAH) and chronic thromboembolic hypertension (CTEPH) typically present with insidious dyspnoea, fatigue, progressive exercise intolerance and occasionally syncope [1].

Sep 13, 2024 | arxiv.org | Simon Schneider

May 23, 2024 | physoc.onlinelibrary.wiley.com | Anna Titz |Simon Schneider |Julian Mueller |Laura Mayer

Mountains cover about a quarter of the continental surface, and more than 500 million humans worldwide live at ≥1500 m (6.58% of the total population) of which 81.6 million live at ≥2500 m above sea level (1.07% of the total population) (Tremblay & Ainslie, 2021). Many high-altitude areas are easily accessible, and physical activities at high altitude are popular.

Mar 7, 2024 | erj.ersjournals.com | Julian Müller |Anna Titz |Simon Schneider |Laura Mayer

DiscussionThe current trial in patients with PAH or distal CTEPH showed that maximal cycling exercise at 2500 m was generally well tolerated. However, the peak work rate was reduced compared with 470 m, along with lower arterial oxygenation and increased ventilation and ventilatory inefficiency.

Feb 29, 2024 | erj.ersjournals.com | Julian Müller |Simon Schneider |Laura Mayer |Anna Titz

AbstractObjective To investigate the effect of a daylong exposure to high altitude on peak exercise capacity and safety in stable patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension (PAH/CTEPH). Methods In a randomised controlled cross-over trial, stable patients with PAH or distal CTEPH without resting hypoxemia at low altitude performed two incremental exercise tests to exhaustion, one after 3–5 h at high (2500 m) and one at low altitude (470 m).