Simon Schneider

Sep 13, 2024 | arxiv.org | Simon Schneider

May 23, 2024 | physoc.onlinelibrary.wiley.com | Anna Titz |Simon Schneider |Julian Mueller |Laura Mayer

Mountains cover about a quarter of the continental surface, and more than 500 million humans worldwide live at ≥1500 m (6.58% of the total population) of which 81.6 million live at ≥2500 m above sea level (1.07% of the total population) (Tremblay & Ainslie, 2021). Many high-altitude areas are easily accessible, and physical activities at high altitude are popular.

Mar 7, 2024 | erj.ersjournals.com | Julian Müller |Anna Titz |Simon Schneider |Laura Mayer

DiscussionThe current trial in patients with PAH or distal CTEPH showed that maximal cycling exercise at 2500 m was generally well tolerated. However, the peak work rate was reduced compared with 470 m, along with lower arterial oxygenation and increased ventilation and ventilatory inefficiency.

Feb 29, 2024 | erj.ersjournals.com | Julian Müller |Simon Schneider |Laura Mayer |Anna Titz

AbstractObjective To investigate the effect of a daylong exposure to high altitude on peak exercise capacity and safety in stable patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension (PAH/CTEPH). Methods In a randomised controlled cross-over trial, stable patients with PAH or distal CTEPH without resting hypoxemia at low altitude performed two incremental exercise tests to exhaustion, one after 3–5 h at high (2500 m) and one at low altitude (470 m).

Oct 25, 2023 | mdpi.com | Lena Reimann |Laura Mayer |Simon Schneider |Esther I. Schwarz

4. DiscussionIn this retrospective study, we investigated the right-to-left shunt fraction (Qs/Qt) in patients with CTEPH whilst breathing pure oxygen (FiO2 1.0) during RHC at baseline and one year after PEA. Among all patients, the median shunt fraction was unchanged 1 year after PEA, but 7/16 (44%) patients improved their shunt fraction (>10% from baseline).