Simona F. Shaitelman

Oct 17, 2024 | digitalcommons.library.tmc.edu | Yu Shen |Jing Ning |Heather Lin |Simona F. Shaitelman

Background: “Old” randomized controlled trials established breast conserving therapy (BCT) and total mastectomy (TM) equivalence for treating early breast cancer, whereas recent literature report improved survival with BCT. To reconcile this, we performed a simulation study and re-analyzed B-06 trial data. Methods: We estimated the distributions for overall survival (OS), cumulative incidence functions for breast-cancer-specific death (BCSD) and other causes-specific death (OCSD) by BCT and TM.