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Jan 8, 2025 | 
mdpi.com | Ning Liu |Shuangcheng Zhang |Xiaoli Wu |Yu Shen
Altmetric announcement Help format_quote Cite thumb_up ... Endorse Need Help? Find support for a specific problem in the support section of our website. Please let us know what you think of our products and services. Visit our dedicated information section to learn more about MDPI.
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Oct 17, 2024 | 
digitalcommons.library.tmc.edu | Yu Shen |Jing Ning |Heather Lin |Simona F. Shaitelman
Background: “Old” randomized controlled trials established breast conserving therapy (BCT) and total mastectomy (TM) equivalence for treating early breast cancer, whereas recent literature report improved survival with BCT. To reconcile this, we performed a simulation study and re-analyzed B-06 trial data. Methods: We estimated the distributions for overall survival (OS), cumulative incidence functions for breast-cancer-specific death (BCSD) and other causes-specific death (OCSD) by BCT and TM.
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Oct 17, 2024 | 
digitalcommons.library.tmc.edu | Helen Johnson |Heather Lin |Yu Shen |Emilia J. Diego
IMPORTANCE: Patients should have an active role in decisions about pursuing or forgoing specific therapies in treatment de-escalation trials. OBJECTIVE: To evaluate longitudinal patient-reported outcomes (PROs) encompassing decisional comfort and health-related quality of life (HRQOL) among patients who elected to enroll in a clinical trial evaluating radiotherapy alone, without breast surgery, for invasive breast cancers with exceptional response to neoadjuvant systemic therapy (NST).
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Oct 17, 2024 | 
digitalcommons.library.tmc.edu | Ziyi Li |Yu Shen |Jing Ning
AbstractTransfer learning has attracted increasing attention in recent years for adaptively borrowing information across different data cohorts in various settings. Cancer registries have been widely used in clinical research because of their easy accessibility and large sample size.
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Oct 17, 2024 | 
digitalcommons.library.tmc.edu | Hong Zhu |Yu Lan |Jing Ning |Yu Shen
AbstractSemi-competing risks data often arise in medical studies where the terminal event (e.g., death) censors the non-terminal event (e.g., cancer recurrence), but the non-terminal event does not prevent the subsequent occurrence of the terminal event. This article considers regression modeling of semi-competing risks data to assess the covariate effects on the respective non-terminal and terminal event times.
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Sep 19, 2024 | 
nature.com | Yu Shen
AbstractClinical trials of active surveillance (AS) for Ductal Carcinoma in Situ (DCIS) are underway. We sought to understand the historical management of biologically favorable DCIS and to determine the outcomes of patients who did not have immediate surgery. Using data from the NCDB from 2004 to 2017, the selected cohort included women >40 years of age, with low or intermediate grade and hormone receptor (HR) positive DCIS. AS was defined as either no surgery or surgery >12 months from diagnosis.
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Mar 12, 2024 | 
biorxiv.org | Saurabh Joshi |Andre Forjaz |Yu Shen |Vasco Queiroga
AbstractThe development of novel imaging platforms has improved our ability to collect and analyze large three-dimensional (3D) biological imaging datasets. Advances in computing have led to an ability to extract complex spatial information from these data, such as the composition, morphology, and interactions of multi-cellular structures, rare events, and integration of multi-modal features combining anatomical, molecular, and transcriptomic (among other) information.
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Mar 10, 2024 | 
biorxiv.org | Saurabh Joshi |Andre Forjaz |Yu Shen |Daniel Xenes
AbstractThe development of novel imaging platforms has improved our ability to collect and analyze large three-dimensional (3D) biological imaging datasets. Advances in computing have led to an ability to extract complex spatial information from these data, such as the composition, morphology, and interactions of multi-cellular structures, rare events, and integration of multi-modal features combining anatomical, molecular, and transcriptomic (among other) information.
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Jan 4, 2024 | 
onlinelibrary.wiley.com | Wei Xu |Yu Shen
CONFLICT OF INTEREST STATEMENT The authors have no conflicts of interest to declare. Supporting Information Filename Description cbdd14433-sup-0001-DataS1.docxWord 2007 document , 137 KB Data S1: cbdd14433-sup-0002-FigureS1.tiffTIFF image, 543.6 KB Figure S1: REFERENCES , , , , , , , , , , , , , & (2022). Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects. Phytotherapy Research, 36(1), 189–213.
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Dec 21, 2023 | 
academic.oup.com | Yu Shen
This study aimed to characterize the first complete genome of Corynebacterium parakroppenstedtii and clarify the evolutionary relationship in the Corynebacterium kroppenstedtii complex (CKC) by using comparative genomics analysis. The genome of isolate yu01 from a breast specimen was sequenced, and 35 CKC genomes were collected. Analysis of 16S rRNA, rpoB, and fusA suggested ambiguous identification, whereas ANI analysis assigned isolate yu01 as C. parakroppenstedtii.
