Simone Baiardi

Jul 18, 2023 | nature.com | Sebastian Palmqvist |Shorena Janelidze |Simone Baiardi |Oskar Hansson

AbstractThere is poor knowledge about the clinical effects of Lewy body (LB) pathology in patients with cognitive impairment, especially when coexisting with Alzheimer’s disease (AD) pathology (amyloid-β and tau). Using a seed amplification assay, we analyzed cerebrospinal fluid for misfolded LB-associated α-synuclein in 883 memory clinic patients with mild cognitive impairment or dementia from the BioFINDER study.