-
Dec 21, 2024 | 
etc.se | Oskar Hansson
När Stockholms trafikregionråd Anton Fendert (MP) nu på test öppnar spärrarna vid Näckrosens tunnelbanestation är det tyvärr mest tom populism. Han vill göra något marginellt positivt för att distrahera från att han skär ner på trafiken och höjer priserna, men utan att behöva göra några egentliga åtaganden. Han är helt enkelt inte beredd att göra tillräckligt stora förändringar för att faktiskt lösa några problem.
-
Oct 12, 2024 | 
alzres.biomedcentral.com | Anna Svenningsson |Diana I. Bocancea |Erik Stomrud |Frederik Barkhof |Niklas Mattsson-Carlgren |Sebastian Palmqvist | +3 more
-
Jul 14, 2024 | 
nature.com | Oskar Hansson
The 2024 update for Alzheimer’s disease (AD) criteria introduces a new biomarker classification system with blood biomarkers and revised staging. AD biomarkers are currently recommended for symptomatic patients within comprehensive clinical evaluations. High-performing p-tau217 assays offer cost-effective diagnostics, comparable to cerebrospinal fluid and PET. International clinical guidelines are being developed to enhance diagnostic and prognostic accuracy.
-
May 31, 2024 | 
lakartidningen.se | Kaj Blennow |Oskar Hansson
Vi har bevittnat imponerande framsteg inom den kliniska forskningen kring Alzheimers sjukdom, vilka gett en detaljerad kunskap om den molekylära patologi som karakteriserar sjukdomen. Dessa patofysiologiska processer innefattar i korthet aggregering av amyloid-beta (Aβ) till Aβ-innehållande plack, fosforylering och aggregering av tau-protein med bildning av neurofibriller i nervcellernas cytoplasma och dystrofiska neuriter som omger placken, samt degeneration av nervceller och deras synapser [1].
-
May 3, 2024 | 
medrxiv.org | Andrea Pilotto |Oskar Hansson |Henrik Zetterberg |Virginia Quaresima
The authors have declared no competing interest. The research is supported by Airalzh Foundation AGYR2021 Life-Bio Grant, the Italian Ministry of University and Research PRIN COCOON (2017MYJ5TH) and PRIN 2021 RePlast (20202THZAW), the Italian Ministry of Health, Grant/Award Number: RF-2018-12366209 and PNRR-Health PNRR-MAD-2022-12376110. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
-
Apr 10, 2024 | 
lakartidningen.se | Oskar Hansson
Replik. Robin Zhou med kollegor kommenterar i Läkartidningen [1] de uppdaterade rekommendationerna för diagnostik och stadieindelning av Alzheimers sjukdom, som har tagits fram av en internationell kommitté ledd av Alzheimer’s Association och som snart kommer att publiceras [2]. Dessvärre verkar det föreligga en del missförstånd.
-
Mar 1, 2024 | 
nature.com | Joseph Therriault |Suzanne Schindler |Gemma Salvadó |Thomas K. Karikari |Melissa Murray |Inge M.W. Verberk | +5 more
AbstractDisease staging, whereby the spatial extent and load of brain pathology are used to estimate the severity of Alzheimer disease (AD), is pivotal to the gold-standard neuropathological diagnosis of AD. Current in vivo diagnostic frameworks for AD are based on abnormal concentrations of amyloid-β and tau in the cerebrospinal fluid or on PET scans, and breakthroughs in molecular imaging have opened up the possibility of in vivo staging of AD.
-
Sep 7, 2023 | 
nature.com | Niclas Eriksson |Erin Macdonald-Dunlop |Stefan Enroth |Domenico Cozzetto |Lasse Folkersen |Christian Herder | +16 more
Correction to: Nature Immunology https://doi.org/10.1038/s41590-023-01588-w, published online 10 August 2023. In the version of the article originally published, the middle panel in Fig. 3b was mistakenly a duplicate of the upper panel. The figure has now been corrected in the HTML and PDF versions of the article.
-
Aug 10, 2023 | 
nature.com | Niclas Eriksson |Erin Macdonald-Dunlop |Stefan Enroth |Domenico Cozzetto |Lasse Folkersen |Christian Herder | +16 more
AbstractCirculating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans).
-
Jul 18, 2023 | 
nature.com | Sebastian Palmqvist |Shorena Janelidze |Simone Baiardi |Oskar Hansson
AbstractThere is poor knowledge about the clinical effects of Lewy body (LB) pathology in patients with cognitive impairment, especially when coexisting with Alzheimer’s disease (AD) pathology (amyloid-β and tau). Using a seed amplification assay, we analyzed cerebrospinal fluid for misfolded LB-associated α-synuclein in 883 memory clinic patients with mild cognitive impairment or dementia from the BioFINDER study.
