Sin-Min Li

Jun 5, 2023 | chemistry-europe.onlinelibrary.wiley.com | Yu-Chieh David Chen |Wei-Zheng Zeng |Sin-Min Li |Jia-Yu Chou

N-1-Piperidonyl amides were firstly oxidized by mCPBA from N-1-piperidinyl amides. The new developed method was also extended to Rimonabant analogue, N-(piperidin-1-yl)-1H-1,2,4-triazole-3-carboxamide, and N-(azepan-1-yl)benzamide, especially for Rimonabant analogue. This work presented a significant advancement in the synthesis of oxidized N-1-piperidonyl amides that had important implications for the further development of potential drugs and the study of the oxidized metabolite.