Yu-Chieh David Chen

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Articles

Temporal and Notch identity determine layer targeting and synapse location of medulla neurons

Jan 5, 2025 | biorxiv.org | Isabel Holguera |Yen-Chung Chen |Yu-Chieh David Chen |Felix Simon

AbstractHow specification mechanisms that generate neural diversity translate into specific neuronal targeting, connectivity, and function in the adult brain is not understood. In the medulla region of the Drosophila optic lobe, neural progenitors generate different neurons in a fixed order by sequentially expressing a series of temporal transcription factors as they age. Then, Notch signaling in intermediate progenitors further diversifies neuronal progeny.
Villanova Hosts Biology Seminar By Yu-Chieh David Chen

Oct 2, 2024 | villanovan.com | Yu-Chieh David Chen |Kristiana Kovaci

Villanova University recently welcomed Yu-Chieh David Chen on Sept. 26, to present a biology seminar on “Wiring up the Brain During Development: Coordination and Propagation of Cell Fate Choice in Neural Circuit Assembly.” The presentation dealt with fruit flies, drosophila and the difference between stochastic and deterministic cell-type determination methods. The room was composed of students, one who was there for their senior thesis, and many members of faculty.
The Impact of Gut Microbiota Changes on Methotrexate-Induced Neurotoxicity in Developing Young Rats

Apr 19, 2024 | mdpi.com | Yu-Chieh David Chen |Chih-Yao Hou |Mei-Hsin Hsu |Li-Tung Huang

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
Reconfigurable Physical Reservoir Enabled by Polarization of Ferroelectric Polymer P(VDF-TrFE) and Interface Charge‐Trapping/Detrapping in Dual‐Gate IGZO Transistor - Chu - Advanced Functional Materials - Wiley Online Library

Dec 2, 2023 | onlinelibrary.wiley.com | Yu-Chieh David Chen |Li-Chung Shih |Shi-Cheng Mao |Fang-Jui Chu

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202310951-sup-0001-SuppMat.pdf3 MB Supporting Information References 1, , Nature 2022, 604, 255. 2, , , , , , , , , Nat. Electron. 2020, 3, 371. 3, , , , , , , Nat. Rev. Mater. 2020, 5, 173. 4, , , , Nat. Rev. Phys. 2021, 3, 671. 5, , , Nat. Electron. 2018, 1, 22. 6, , , , Nat. Nanotechnol. 2020, 15, 812. 7, , , , , , , , , , ACS Nano 2018, 12, 11263.
Toward building a library of cell type–specific drivers across developmental stages | Proceedings of the National Academy of Sciences

Aug 17, 2023 | pnas.org | Yu-Chieh David Chen |Donald B. Miles |Robert E. Ricklefs |Jonathan B. Losos

Get full access to this articlePurchase, subscribe or recommend this article to your librarian. AcknowledgmentsC.L. was supported by the Stanford Science Fellows Program. Author contributionsC.L., Z.L. and L.L. wrote the paper. Competing interestsThe authors declare no competing interest. ReferencesE. Z. Kvon et al., Genome-scale functional characterization of Drosophila developmental enhancers in vivo. Nature 512, 91–95 (2014). L. Tirian, B. J.
Sustaining the Activation of EGFR Signal by Inflammatory Cytokine IL17A Prompts Cell Proliferation and EGFR-TKI Resistance in Lung Cancer

Jun 22, 2023 | mdpi.com | Kai-Ling Lee |Tsung-Ching Lai |Wei-Jiunn Lee |Yu-Chieh David Chen

Open AccessArticle by Kai-Ling Lee 1,2, Tsung-Ching Lai 3,4, Wei-Jiunn Lee 1,5,6, Yu-Chieh Chen 1, Kuo-Hao Ho 1, Wen-Yueh Hung 1, Yi-Chieh Yang 1,7, Ming-Hsien Chan 8, Feng-Koo Hsieh 9, Chi-Li Chung 2,10, Jer-Hwa Chang 3,4,10,* and Ming-Hsien Chien 1,4,11,12,* 1 Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan 2 Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110301, Taiwan...
One‐Pot Double Oxidation Synthesis of N‐1‐Piperidonyl Amides From N‐1‐Piperidinyl Amides with meta‐Chloroperbenzoic Acid: Rimonabant Analogue as Model Study

Jun 5, 2023 | chemistry-europe.onlinelibrary.wiley.com | Yu-Chieh David Chen |Wei-Zheng Zeng |Sin-Min Li |Jia-Yu Chou

N-1-Piperidonyl amides were firstly oxidized by mCPBA from N-1-piperidinyl amides. The new developed method was also extended to Rimonabant analogue, N-(piperidin-1-yl)-1H-1,2,4-triazole-3-carboxamide, and N-(azepan-1-yl)benzamide, especially for Rimonabant analogue. This work presented a significant advancement in the synthesis of oxidized N-1-piperidonyl amides that had important implications for the further development of potential drugs and the study of the oxidized metabolite.
Pharmaceuticals | Free Full-Text | Increased Circulating ADMA in Young Male Rats Caused Cognitive Deficits and Increased Intestinal and Hippocampal NLRP3 Inflammasome Expression and Microbiota Composition Alterations: Effects of Resveratrol

May 31, 2023 | mdpi.com | Yi-Chuan Huang |Yu-Chieh David Chen |Mei-Hsin Hsu |Jiunn-Ming Sheen

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticlebyMei-Hsin Hsu 1,†, Yi-Chuan Huang 1,†, Yu-Chieh Chen 1, Jiunn-Ming Sheen 2 and Li-Tung Huang 1,* 1Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 833, Taiwan2Chiayi Chang Gung Memorial Hospital, Puzi City 613, Taiwan*Author to whom correspondence should be addressed. †These authors contributed equally to this work.
Using single-cell RNA sequencing to generate cell-type-specific split-GAL4 reagents throughout development

Feb 4, 2023 | biorxiv.org | Yu-Chieh David Chen |Yen-Chung Chen |Raghuvanshi Rajesh |Nathalie Shoji

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Yu-Chieh David Chen

Articles

Temporal and Notch identity determine layer targeting and synapse location of medulla neurons

Villanova Hosts Biology Seminar By Yu-Chieh David Chen

The Impact of Gut Microbiota Changes on Methotrexate-Induced Neurotoxicity in Developing Young Rats

Reconfigurable Physical Reservoir Enabled by Polarization of Ferroelectric Polymer P(VDF-TrFE) and Interface Charge‐Trapping/Detrapping in Dual‐Gate IGZO Transistor - Chu - Advanced Functional Materials - Wiley Online Library

Toward building a library of cell type–specific drivers across developmental stages | Proceedings of the National Academy of Sciences

Sustaining the Activation of EGFR Signal by Inflammatory Cytokine IL17A Prompts Cell Proliferation and EGFR-TKI Resistance in Lung Cancer

One‐Pot Double Oxidation Synthesis of N‐1‐Piperidonyl Amides From N‐1‐Piperidinyl Amides with meta‐Chloroperbenzoic Acid: Rimonabant Analogue as Model Study

Pharmaceuticals | Free Full-Text | Increased Circulating ADMA in Young Male Rats Caused Cognitive Deficits and Increased Intestinal and Hippocampal NLRP3 Inflammasome Expression and Microbiota Composition Alterations: Effects of Resveratrol

Using single-cell RNA sequencing to generate cell-type-specific split-GAL4 reagents throughout development

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