Sina Khorsandi

2 weeks ago | advanced.onlinelibrary.wiley.com | Sina Khorsandi |Kristin Huntoon |Yifan Wang |Adam Woodward

Graphical Abstract Cancer Therapy Gas-filled microbubbles, guided by antibody-receptor binding, selectively target APCs. Ultrasound pulses at the tumor site trigger microbubble oscillation and collapse, generating mechanical forces that transiently disrupt the APC membrane. This process enables efficient cytosolic delivery of STING agonists via sonoporation, bypassing endosomal barriers and enhancing intracellular drug availability for immune activation.

Mar 26, 2025 | advanced.onlinelibrary.wiley.com | Sina Khorsandi |Kristin Huntoon |Yifan Wang |Adam Woodward

1 Introduction The clinical successes of immune checkpoint inhibitors (ICIs) have ushered in a renaissance era for immunotherapy, as ICIs are now the standard-of-care for many cancer types.[1] However, patient response to ICIs remains highly heterogeneous, with the majority of patients showing little to no response at all.[2] A potential reason for the low efficacy seen in many patients is from a lack of innate immune activation.