Siwei Chen

Oct 2, 2024 | biorxiv.org | Wenhan Lu |Siwei Chen |Danielle Posthuma |Benjamin M. Neale

AbstractGenome-wide association studies (GWAS) and rare-variant association studies (RVAS) have identified thousands of genes and variants that affect multiple phenotypes. Here, using rare variant association results from the UK Biobank (UKB) data, we identify pervasive gene-level pleiotropy across diverse phenotypic domains and highlight genes with apparent allelic series that provide additional association support through disease pathways.

Jan 24, 2024 | mdpi.com | He Zhang |Yutong Wang |Yu Qi |Siwei Chen

1. IntroductionNatural and cultural environments have gradually become viewed as a holistic entity with the emergence of cultural ecology in the early 20th century []. In 1972, the United Nations Educational, Scientific and Cultural Organization (UNESCO) formulated the “Convention Concerning the Protection of the World Cultural and Natural Heritage”, which formally proposed the joint protection of natural and cultural heritage as assets of universal value [].