Wenhan Lu

Oct 2, 2024 | biorxiv.org | Wenhan Lu |Siwei Chen |Danielle Posthuma |Benjamin M. Neale

AbstractGenome-wide association studies (GWAS) and rare-variant association studies (RVAS) have identified thousands of genes and variants that affect multiple phenotypes. Here, using rare variant association results from the UK Biobank (UKB) data, we identify pervasive gene-level pleiotropy across diverse phenotypic domains and highlight genes with apparent allelic series that provide additional association support through disease pathways.

Aug 26, 2024 | medrxiv.org | Jinyoung Byun |Yixuan He |Wenhan Lu |Yon Ho Jee

MHC has received grant support from GSK, consulting fees from Genentech and AstraZeneca, and speaking fees from Illumina. ARM has received speaker fees from Novartis. MM has received consulting fees from TheaHealth, 2ndMD, Axon Advisors, Verona Pharma, and Sanofi. All other authors declare no competing interests. This work was supported by the National Institutes of Health under award number T32HG010464, K99/R00MH117229, U01HG011719.

Mar 15, 2024 | medrxiv.org | Konrad J Karczewski |Rahul Gupta |Masahiro Kanai |Wenhan Lu

K.J.K. is a consultant for Tome Biosciences, AlloDx, and Vor Biosciences, and a member of the scientific advisory board of Nurture Genomics. M.J.D is a founder of Maze Therapeutics. B.M.N. is a member of the scientific advisory board at Deep Genomics and Neumora. This work was supported by the Novo Nordisk Foundation (NNF21SA0072102), NIH grants R37MH107649, R00MH117229, K01MH121659, F31HL167378, and F30AG074507, and BroadIgnite funding.