Sladjana Slavkovic

Oct 21, 2024 | biorxiv.org | Aron A. Shoara |Sladjana Slavkovic |Miguel Neves |Preeti Bhoria

AbstractApolipoprotein A-IV (apoA-IV) is an abundant lipid-binding protein in blood plasma. We previously reported that apoA-IV, as an endogenous inhibitor, competitively binds platelet αIIbβ3 integrin from its N-terminal residues, reducing the potential risk of thrombosis. This study aims to investigate how the apoA-IVQ360H and apoA-IVT347S mutations affect the structure and function of apoA-IV.