Aron A. Shoara

Jan 13, 2025 | onlinelibrary.wiley.com | Aron A. Shoara |Temerty Faculty |Kanwal Singh |Development Canada

ADAMTS13 a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 BCA bicinchoninic acid BLI biolayer interferometry CF clot formation CFT clot formation time CT clotting time DCR damage control resuscitation DLS dynamic light scattering DSC differential scanning calorimetry ELISA enzyme-linked immunosorbent assay FDP freeze-dried plasma FFP fresh frozen plasma GP glycoprotein HSA human serum albumin HDL high density lipoprotein HEPES 4-(2-hydroxyethyl)-1-piperazine...

Oct 21, 2024 | biorxiv.org | Aron A. Shoara |Sladjana Slavkovic |Miguel Neves |Preeti Bhoria

AbstractApolipoprotein A-IV (apoA-IV) is an abundant lipid-binding protein in blood plasma. We previously reported that apoA-IV, as an endogenous inhibitor, competitively binds platelet αIIbβ3 integrin from its N-terminal residues, reducing the potential risk of thrombosis. This study aims to investigate how the apoA-IVQ360H and apoA-IVT347S mutations affect the structure and function of apoA-IV.