Sofia Nicolayevsky

May 22, 2024 | biorxiv.org | Danielle Guez-Barber |Sofia Nicolayevsky |Kaya Johnson |Sanghee Yun

AbstractBackground: Rodent models for perinatal hypoxic ischemic (HI) encephalopathy have reported sex differences such as the same injury causing larger lesions in the brains of males compared to females. Microglia, the resident immune cells of the brain that have sex-dependent developmental trajectories and gene expression patterns, likely play a different role in females and males following HI.

Oct 17, 2023 | biorxiv.org | Danielle Guez-Barber |Kaya Johnson |Sanghee Yun |Sofia Nicolayevsky

AbstractBackground: Rodent models for perinatal hypoxic ischemic (HI) encephalopathy have reported sex differences such as males having larger brain lesions than females after the same injury. Microglia, the resident immune cells of the brain that have distinct developmental trajectories and gene expression patterns by sex, likely play a different role in males and females following HI.